Genome mining for drug discovery: cyclic lipopeptides related to daptomycin
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چکیده
منابع مشابه
Genome mining: Prediction of lipopeptides and polyketides from Bacillus and related Firmicutes
Bacillus and related genera in the Bacillales within the Firmicutes harbor a variety of secondary metabolite gene clusters encoding polyketide synthases and non-ribosomal peptide synthetases responsible for remarkable diverse number of polyketides (PKs) and lipopeptides (LPs). These compounds may be utilized for medical and agricultural applications. Here, we summarize the knowledge on structur...
متن کامل[Oxazolidinones, glycopeptides and cyclic lipopeptides].
A review of the chemical structure, pharmacokinetics, spectrum of activity, clinical use, and adverse effects of oxazolidinones (linezolid), glycopeptides, and cyclic lipopeptides (daptomycin) is presented. Oxazolidinones inhibit protein synthesis, and glycopeptides and cyclic lipopeptides act against the bacterial cell wall. The antibacterial spectrum of these agents covers gram-positive patho...
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The main task of drug discovery is to find novel bioactive molecules, i.e., chemical compounds that, for example, protect human cells against a virus. One way to support solving this task is to analyze a database of known and tested molecules in order to find structural properties of molecules that determine whether a molecule will be active or inactive, so that future chemical tests can be foc...
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The text mining community has shown significant impact for use of text mining in drug discovery and basic research. So far, there have been a lot of point solutions that have solved a particular problem or augmented a valuable database. The next step is integrating text mining as part of the entire literature analytic solution and delivering it effectively and comprehensively to support researc...
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The two text mining strategies: finding co-occurrences of biological entities within documents, and finding relationships using Natural Language Processing, are often seen as competitors. Here we adopt a flexible approach where the techniques are adapted and combined to suit the nature of the document corpus, and the specific task. The approach was tested on three tasks relevant to cancer treat...
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ژورنال
عنوان ژورنال: Journal of Industrial Microbiology and Biotechnology
سال: 2021
ISSN: 1367-5435,1476-5535
DOI: 10.1093/jimb/kuab020